Investigation of in vivo antidiabetic, analgesic, and CNS depressant properties of Lagerstroemia thorelli leaf extract

Abstract

Plants in the Lythraceae family are well-known for having anti-inflammatory, analgesic, and antidiabetic qualities. However, through a comprehensive literature search it was found that the antidiabetic, analgesic, and CNS depressant properties of Lagerstroemia thorelli (L. thorelli) have not yet been investigated. This research involved the use of the ethanol leaf extract of Lagerstroemia thorelli at doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg in Swiss albino mice. The antidiabetic effect was assessed in alloxan-induced diabetic mice, the analgesic activity was detected using the acetic acid-induced writhing test, and the CNS depressant effect was determined using the hole cross method. The plant extract exhibited a dose-dependent, statistically significant (P<0.01) antidiabetic, remarkable analgesic and CNS depressant properties. Thus, the present study suggests that extract of Lagerstroemia thorelli could be an effective treatment for diabetes.