Zebrafish, a model for evaluating the pharmacokinetics of the drugs a comprehensive review

Abstract

To facilitate the broad use of zebrafish in drug discovery, it is essential to know the pharmacokinetic since how the body reacts with a molecule and the drug concentration at the designated site depends on it. The potential effect of a molecule can be revealed in a short time through zebrafish with high accuracy and precision. Zebrafish is considered the second most popular animal in research however; a limited scope of zebrafish research is currently available in Bangladesh. More research is required focusing on zebrafish-based pharmacokinetics, toxicology, gene editing studies to extrapolate the conducted data into mammalian models. This review summarizes the recent research that has been conducted on zebrafish whether from current medicine or xenobiotics: environment contaminants, crude chemicals, etc. to demonstrate and compare the working procedure and extrapolation on human model.