Study on the methods of the moisture content determination of active pharmaceutical ingredients recommended by the British pharmacopoeia

Abstract

The weight of water contained in an object or material is referred to as moisture content (or water content). The karl fischer titration, azeotropic distillation, and the loss on drying method are the three basic methods for determining the moisture content of pharmaceutical compounds. Karl Fischer titration is a classic titration method in chemical analysis that determines tiny amounts of water in a sample using coulometric or volumetric titration. Azeotropic distillation is the technique of using distillation to separate the components of an azeotropic mixture. Loss on drying is a common test method for determining a sample's moisture content, although it can also define as the loss of any volatile matter from the sample. For the determination of water, the maximum of the APIs follow after the loss on drying method.