A technological review on dry powder inhaler formulations with and without carriers

Abstract

This review mainly focuses on the advanced technologies used in the development of dry powder inhaler (DPI) formulations. There are several conventional techniques existing till date which were used to develop DPI formulations. But they have become ineffective to deal with current problems. Therefore, in this review modern technologies of DPI formulations with or without carriers have been discussed briefly to figure out the better one based on their advantages and disadvantages such as pulmosphere is a technique which gives the drug particles a smooth surface texture and the deposition is considered enough to be effective in the body on the other hand spray drying gives good amount of deposition in the lungs by providing carriers with coarse surface and by increasing the flow ability. Though no technology is perfect but most of these advanced technologies are giving better results in case of deposition in the lungs than the past methods. Also, these technologies are on their way for further development in future in terms of better flow ability, less aggregation, higher deposition and lower toxicity in the body. To conduct this study, Science Direct, Sci-Hub have been used for collecting the scientific evidence and experimental data regarding the review.